Constance Therapeutics produces whole plant cannabis extracts as part of an integrative approach to treatment, providing physicians and their patients with expanded options in cases where only pharmaceuticals may have been prescribed in the past. Constance Therapeutics’ tightly controlled, quantitatively-defined and patent-pending extraction method, which only uses pharmaceutical grade, certified-organic ethanol, is based on scientific and engineering principles. Big Rock made investments in Constance Therapeutics 2016-2017.